Preoperative Goserelin on decreasing bleeding during transurethral resection of prostate

Objective To evaluate the influence and mechanism of preoperative Goserelin on decreasing bleeding during transurethral resection of prostate(TURP).Methods A randomized controlled experiment was carried out.A total of 90 patients with benign prostatic hyperplasia,who were to receive TURP treatment,were divided into three groups(Group A,B and C) with 30 patients in each.Group A received Finasteride for 4 weeks before TURP(5 mg/d),Group B subcutaneous injection of 3.6 mg Goserelin Acetate for 22 days,and Group C was the control group.The weight of removed prostatic tissue and the volume of bleeding of each group were compared.Micro vessel density(MVD) and vascular endothelial growth factor(VEGF) expressions in prostatic tissue were measured with ISH SP-method.Results There was no significant difference in the mean weight of removed prostatic tissue,but there was statistic difference in the mean volume of operative bleeding,bleeding after 1 g prostatic tissue removed,MVD,the area of microvascular cavity,and the mean positive cell count of VEGF(P0.05).Conclusions VEGF expression and angiogenesis in the prostate tissue are suppressed and blooding during TURP is decreased by the use of preoperative Goserelin,which causes no side effect and therefore is more effective than Finasteride.