The Diagnostic Value of Blood β_2-microglobulin in Kidney Lesion after Neonatal Asphyxia

Objective To analyze the clinical diagnostic value of β2-microglobulin(β2-MG) in kidney lesion after neonatal asphyxia by detecting the content of β2-MG in blood.Methods 30 newborns with severe neonatal asphyxia and 40 mild neonatal asphyxia were chosen as the observation group,and 20 healthy newborns as the control group.The radio-immunity assay was used to detect the content of β2-MG in blood.Blood urea nitrogen(BUN) and creatinine(Cr),the routine indices to evaluate renal function,were simultaneously measured as comparison.The data was analyzed with statistics software.Results Compared with healthy newborns,the levels of β2-MG,BUN and Cr in blood were significantly increased in neonatal asphyxia(P0.05),and the level of β2-MG was significantly higher in the newborns with severe asphyxia than mild asphyxia(P0.05),and the level of β2-MG increased more obviously(in 24 hours) than that of BUN and Cr in blood of newborns with asphyxia.Conclusion β2-MG is more appropriate to be used as the routine index to evaluate early kidney lesion after neonatal asphyxia.