2004•Research and Practice on Chinese MedicinesRequires access

Determination of Chlorogenic in Yanhoushuang Oral Liquid by HPLC

MO Hai-ling

Abstract

Objective To control the quality of Yanhoushuang Oral Liquid and establish the determination of chlorogenic acid in the liquid. Methods HPLC was used to determine the content of chlorogenic acid on ODS-2 column with a mobile phase of acetonitrile-0.01% mol/L Potassium dihydrogen phosphate(6∶94). pH was adjusted to 3.0 by acetic acid.UV detection wavelength was set at 326 nm.Results chlorogenic acid standard showed a good linear relationship at a range of 0.206 8～2.068 μg, r= 0.999 99 ;The average recovery was 101.7% (RSD=1.04%,n=6). Conclusion This method is convenient,quick,accurate and available for the quality control of Yanhoushuang Oral Liquid.

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Key concepts: Chlorogenic acid, Chromatography, High-performance liquid chromatography, Chemistry, Acetic acid, Potassium, Acetonitrile, Linear range