Effects of amlodipine combined with valsartan on the blood pressure,endothelin-1 and NO in elderly patients with hypertension

Objective To observe the effect of amlodipine combined with valsartan on the blood pressure,endothelin(ET-1) and NO in elderly patients with hypertension.Methods Forty cases of elderly patients with hypertension were randomly divided into two groups of 20 cases in each group.Observation group were given amlodipine and valsartan combination therapy,the control group only received valsartan,compared two groups' blood pressure,ET-1,NO and vascular elasticity index changes.ResuItB Two groups 2,4,6,8 weeks after treatment,compared with pre-treatment,blood pressure were dropped,and the observation group decreased more signiiicandy than in the control group(P 0.05);compared with before treatment,2 groups after 8 weeks of treatment,ET-1,NO were improved(P 0.05),and observation group significandy improved compared with the control group(P 0.05);in both groups after 8 weeks of treatment,arterial elastic index(C_1,C_2)increased than those before treatment,and observation group significandy higher than the control group(P 0.05);after 8weeks of treatment,in two groups pulse ware velocity(PWV) and ankle-brachial index were better than those pre-treatment,observation group was better than control group(P 0.05).2 groups' incidence of adverse reactions was showed no significant difference(P 0.05).Conclusion It's demonstrated that the amlodipine combined with valsartan had good efficacy in elderly hypertensive patients the antihypertensive effect is obvious,ET-1 were significandy decreased,NO were significandy increased,vascular elastic function were improved.