Effective Comparision of 'Supplementing Qi and Invigorating Spleen' and 'Nourishing Yin and Harmonizing Stomach' on Gastric Motility and Gastric Blood Flow in Rats of Diabetic Gastroparesis Model

Objective:To compare the effects of 'supplementing qi and invigorating spleen' and 'nourishing yin and harmonizing stomach' on gastric motility and gastric blood flow in rats of diabetic gastroparesis model.Method: One hundred and twenty SD rats,were divided into the normal group(n=16) and model group(n=104).Rats were intraperitoneally injected streptozotocin(STZ) solution(70 mg·kg-1) to establish diabetic models.After 72 hours,we tested blood glucose levels of rats and rats that blood glucose levels less than 11 mmol·L-1 were expelled.Seven weeks later,medel rats were randomly assigned into seven groups,such as the model group,supplementing qi-high group(20 g·kg-1·d-1),supplementing qi-low group(5.5 g·kg-1·d-1),nourishing yin-high group(27 g·kg-1·d-1),nourishing yin-low group(7.8 g·kg-1·d-1),metformin group(125 mg·kg-1·d-1),domperidone group(3.5 g·kg-1·d-1).The administration time last 6 weeks.Thirty minutes after the last administration,blood glucose,gastric motility and gastric blood flow were determined.Result: Gastric motility and gastric blood flow of model rats were both reduced greatly compared with the normal rats(P0.05).Gastric motility and gastric blood flow of administration groups,especially of supplementing qi-high,nourishing yin-high and domperidone groups,increased greatly compared with rats of model group(P0.01).Conclusion: Both of 'supplementing qi and invigorating spleen' and 'nourishing yin and harmonizing stomach' methods can improve gastrointestinal function in rats of diabetic gastroparesis Model by increasing gastric motility and gastric blood flow.'nourishing yin and harmonizing stomach' has certain treatmental advantage than 'supplementing qi and lnvigorating spleen' which conformed the Chinese medicine theory that diabetes belonged to 'yin-deficiency' syndrom.