Expression of osteopontin and NF-κB/p65 in breast caner and its clinical significance

Objective To evaluate the expression of osteopontin(OPN)and NF-κB/p65 in breast cancer,and its relationship with histological grading,lymph node metastasis,the expression of hormonal-receptor as well as the correlation of them.Methods Immunohistochemical(Eli Vision)method was used to detect the expression of OPN and NF-κB/p65 in eighty pathological confirmed and surgical resected breast cancer,and forty noncancerous breast tissue.Results The high positive rates of the expression of OPN and NF-κB/p65 in breast cancer were 63.8%(51/80)and 61.3%(49/80).The high expression of them in noncancerous breast tissue were 15.0%(6/40)and 20.0%(8/40).The high expression level of OPN and NF-κB/p65 had correlation with histological grading,axillary node metastasis(P0.05),and that of NF-κB/p65 also had correlation with the expression of HER-2(P0.05),but had no correlation with histological grading,stage of TNM,size of breast cancer,ER,PR and HER-2(P0.05).OPN was positively correlated with NF-κB/p65 in breast cancer(P0.05).Conclusion The high expression of OPN and NF-κB/p65 in breast cancer is higher than that in noncancerous breast tissue,which is correlated with the biological behavior of breast cancer,and a joint detection of them might be an important marker and prognostic factor in breast cancer.