Effect of Rosiglitazone on Human Renal Tubule Cell Growth Cultured in High Glucose Medium

[Objective] To study the effect of rosiglitazone(RGZ)on HK-2 cells proliferation in high glucose medium.[Methods]The cell proliferation was detemined with MTT method at 24h、48h、72h respectively after HK-2 cells were incubated with high glucose or high glucose plus RGZ.[Results]①At 24h,in comparison with LG group,the proliferation of HK-2 cells in HG group was decreased insignificantly.At 48h and 72h,in comparison with LG group,the proliferation of HG group was increased significantly;②At 24h,the proliferation of HG+R groups was lower than that of LG group markedly.At 48h and 72h,the proliferation of HG+R groups was higher than that of LG group markedly,as well,in a dose-dependent manner;in comparison with HG group,the proliferation of HG+R groups was increased and the difference was significant at 72h(P0.01).[Conclusion] ①Exposure of HK-2 cells to high glucose induces a time-dependent dual effect consisting of an early apoptosis and a late proliferation;②During the observation,the effect of Rosiglitazone on HK-2 cells growth cultured in high glucose medium is facilitative mainly.