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2009•Anhui Medical and Pharmaceutical JournalRequires access

Effects of simvastatin on expression of matrix metalloproteinase-9 in human umbilical vein endothelial cells

YU Wei-nan

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Abstract

Aim To investigate the effects of simvastatin on expression of matrix metalloproteinase-9(MMP-9) in human umbilical vein endothelial cells(HUVEC).Methods HUVEC were cocultured with different concent-ration of simvastatin for different time.MMP-9 protein and mRNA expression in HUVEC were measured by Western blotting and reverse transcription polymerase chain reaction(RT-PCR).Result Incubation of HUVEC with simvastatin resulted in an decreasing expression of protein and mRNA of MMP-9 in a concentration and time-dependent manner.Conclusion Simvastatin decreases the expression of MMP-9 in HUVEC.

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What this paper is about

Aim To investigate the effects of simvastatin on expression of matrix metalloproteinase-9(MMP-9) in human umbilical vein endothelial cells(HUVEC).Methods HUVEC were cocultured with different concent-ration of simvastatin for different time.MMP-9 protein and mRNA expression in HUVEC were measured by Western blotting and reverse transcription polymerase chain reaction(RT-PCR).Result Incubation of HUVEC with simvastatin resulted in an decreasing expression of protein and mRNA of MMP-9 in a concentration and time-dependent manner.Conclusion Simvastatin decreases the expression of MMP-9 in HUVEC.

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Available abstract

Aim To investigate the effects of simvastatin on expression of matrix metalloproteinase-9(MMP-9) in human umbilical vein endothelial cells(HUVEC).Methods HUVEC were cocultured with different concent-ration of simvastatin for different time.MMP-9 protein and mRNA expression in HUVEC were measured by Western blotting and reverse transcription polymerase chain reaction(RT-PCR).Result Incubation of HUVEC with simvastatin resulted in an decreasing expression of protein and mRNA of MMP-9 in a concentration and time-dependent manner.Conclusion Simvastatin decreases the expression of MMP-9 in HUVEC.

Key concepts: Simvastatin, Umbilical vein, Matrix metalloproteinase, Messenger RNA, Blot, Reverse transcription polymerase chain reaction, Molecular biology, Metalloproteinase

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