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2004•Chinese Journal of ArteriosclerosisRequires access

The Effects of Simvastatin on the Expression of Vascular Cell Adhesion Molecule in Human Umbilical Vein Endothelial Cell

Lu Zhang, Zonggui Wu

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Abstract

Aim To investigate the effects of Simvastatin on the expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) in cultured human umbilical vein endothelial cell (hUVEC). Methods The effects of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and Simvastatin on the protein levels of VCAM-1 and ICAM-1 in hUVEC were observed by means of immunocytochemistry and Western blot. Results TNF-α and IL-1β significantly upregulated the protein levels of VCAM-1 and ICAM-1 in hUVEC,which were inhibited by Simvastatin. Conclusion Simvastatin inhibited the upregulations of VCAM-1 and ICAM-1 stimulated by proinflammatory factors, which may increase the stability of plaques and decelerate the progression of atherosclerosis.

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What this paper is about

Aim To investigate the effects of Simvastatin on the expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) in cultured human umbilical vein endothelial cell (hUVEC). Methods The effects of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and Simvastatin on the protein levels of VCAM-1 and ICAM-1 in hUVEC were observed by means of immunocytochemistry and Western blot. Results TNF-α and IL-1β significantly upregulated the protein levels of VCAM-1 and ICAM-1 in hUVEC,which were inhibited by Simvastatin. Conclusion Simvastatin inhibited the upregulations of VCAM-1 and ICAM-1 stimulated by proinflammatory factors, which may increase the stability of plaques and decelerate the progression of atherosclerosis.

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Available abstract

Aim To investigate the effects of Simvastatin on the expression of vascular cell adhesion molecule-1 (VCAM-1) and intercellular adhesion molecule-1 (ICAM-1) in cultured human umbilical vein endothelial cell (hUVEC). Methods The effects of tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β) and Simvastatin on the protein levels of VCAM-1 and ICAM-1 in hUVEC were observed by means of immunocytochemistry and Western blot. Results TNF-α and IL-1β significantly upregulated the protein levels of VCAM-1 and ICAM-1 in hUVEC,which were inhibited by Simvastatin. Conclusion Simvastatin inhibited the upregulations of VCAM-1 and ICAM-1 stimulated by proinflammatory factors, which may increase the stability of plaques and decelerate the progression of atherosclerosis.

Key concepts: Simvastatin, Umbilical vein, Cell adhesion molecule, Immunocytochemistry, Human umbilical vein endothelial cell, Tumor necrosis factor alpha, Proinflammatory cytokine, Intercellular Adhesion Molecule-1

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The Effects of Simvastatin on the Expression of Vascular Cell Adhesion Molecule in Human Umbilical Vein Endothelial Cell — Research Paper | ScholarLens