2004•Academic Journal of Second Military Medical UniversityRequires access

Effects of simvastatin on expression of vascular endothelial growth factor in human umbilical vein endothe lial cells

Lu Zhang

Abstract

Objective:To investigate the effect of simvastatin on the expression of vascular endothelial growth factor (VEGF)and its receptor in cultured human umbilical vein endothelial cells(HUVEC).Methods:Cells were randomly divided into simvastatin group,tumor necrosis factor-α(TNF-α)group,simvastatin+TNF-αgroup,interleukin-1β(IL-1β)group,simvastatin+IL-1βgroup and control group.The effects of TNF-α,IL-1βand simvastatin on the protein levels of VEGF and its receptor in HUVEC were studied by immunocytochemistry.Results:The protein levels of VEGF and its receptor in TNF- αgroup and IL-1βgroup were significantly higher than those of control group,and simvastatin decreased the protein levels of VEGF and its receptor in TNF-αgroup and IL-1βgroup.Conclusion:Simvastatin can decrease the protein levels of VEGF and its receptor in HUVEC. [

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Key concepts: Simvastatin, Umbilical vein, Tumor necrosis factor alpha, Vascular endothelial growth factor, Immunocytochemistry, Endocrinology, Internal medicine, Medicine