Microvessel Density and CD44v6 Expression in Uterine Cervical Squamous Carcinoma and Their Clinical Significance

Objective To analyse the microvascular density(MVD) and CD44v6 expression in uterine cervical squamous carcinoma to evaluate their clinical significance. Methods Immunohistochemical staining (LSAB method) by using antibodies against CD 34 and CD44v6 was performed on archival specimens of 50 cases of human uterine cervical squamous carcinoma and 10 cases of normal cervical tissue. Results MVD was greater in metastatic tumors than that in nonmetastatic tumors and normal control. The expression of CD44v6 was higher in metastatic tumors than that in nonmetastatic tumors and normal control. MVD and CD44v6 expressions were significantly related to lymph node metastasis(P0 01).The expression of CD44v6 in the invasive carcinoma increased compared with carcinoma in situ and early invasive carcinoma(P0 05). Conclusions MVD and the CDv44v6 expression levels were associated with invasion and metastasis of uterine cervical cancer. MVD and CD44v6 positive expression may be used as a hopeful marker for predicting the prognosis and metastasis of patients with uterine cervical cancer.