Effect of granule of Jiawei Bushen Zhuangjin dection on serum NO and SOD in ovariectomized osteoporosis rats

Objective To explore the changes of serum NO and SOD and the effects of granule of Jiawei Bushen Zhuangjin dection in ovariectomied osteoporosis rats.Methods Fourty five female Wistar rats aged 6 months were divided into three groups randomly: control group, model group and herb granular group. The ovaries excision formed the rat model of osteoporosis in model group and herb granular group. Herb granular was given to stomach of rats in herb granular group with 6.7 ml/(kg·d)after ovariectomy, while 6.7 ml/(kg·d) and 0.9% sodium chloride were given in control group and model group respectively in the same way. Serum levels of NO and SOD were measured before and 3 months after ovariectomy.Results 3 months after ovariectomy, it is found that much lower NO and SOD levels in model group than those in control group. Compared with model group, the levels of NO and SOD in serum evidently raised after using granule of Jiawei Bushen Zhuangjin dection(P0.05).Conclusion Serum NO and SOD may participate in the pathological process of postmenopausal osteoporosis. Granular of Jiawei Bushen Zhuangjin dection may regulate serum levels of NO and SOD, which may be the mechanism of the drug for preventing and treating osteoporosis.