Empirical Studies on Treatment Effects of Bushen Tongluo Decoction in Osteoporosis Rats

Objective:To observe the intervention effects and mechanism of Bushen Tongluo decoction on bone metabolism and density in the osteoporosis rats.Method:Rat models of the osteoporosis were established by bilateral ovariotomy.The rats were divided into six groups randomLy:the nomal group,model group,XinLinGuBao group,Bushen-based decoction group,Tongluo decoction group,Bushen Tongluo decoction group.After ten weeks treatment,the rats weight,the serum calcium,the serum phosphorus,the serum alkaline phosphatase and the bone density.Result:The weight of the osteoporosis rats increased,the serum calcium decreased,the serum phosphorus increased,the serum alkaline phosphatase increased and the bone density decreased in model group as compared with the normal group(P 0.05).The weight gain of the osteoporosis rats were inhibited in each treat group as compared with model group,but there were no significant difference.The serum calcium increased,the serum phosphorus decreased in each treat group as compared with model group,and there were significant difference in Bushen Tongluo decoction group.The serum alkaline phosphatase decreased obviously in each group as comparedwith model group(P0.01).The bone density increased in each group as compared with model group,and therewere significant difference in Bushen-based decoction group.(P0.05)and in Tongluo decoction group andBushen Tongluo decoction group(P0.01).The numerus of Bushen Tongluo decoction group were higher than thenumerus of Bushen-based decoction group or Tongluo decoction group.Conclusion:Bushen Tongluo decoction groupcan effectively decrease high dysbolism of bone metabolism,increase bone density in the osteoporosis rats.Bushendecoction and Tongluo decoction have good synergism.