Contrast study of synergistic effect of Quetiapine and Olanzapine on patients with depression combined with anxiety disorder treated with Paroxetine

Objective: To compare efficacy and safety of Paroxetine combined with Quetiapine or Olanzapine in treatment of patients with depression combined with anxiety disorder. Methods: 60 patients suffering from depression with anxiety disorder were randomly divided into Paroxetine combined with Quetiapine group( n = 30,combined Quetiapine group) and Paroxetine combined with Olanzapine group( n = 30,combined Olanzapine group). The treatment continued for eight weeks. Hamilton depression scale( HAMD),Hamilton anxiety scale( HAMA),and treatment emergent symptom scale( TESS) were used to evaluate efficacy and adverse reactions. Results: One week after the treatment,the scores of HAMD and HAMA of the two groups decreased compared with those before the treatment,the differences of the same group were significant( P 0. 01); however,the differences between the two groups were insignificant( P 0. 05). No big difference between the two groups in the obvious effective rate( P 0. 05). For the adverse reactions( nausea,dry mouth,constipation,tachycardia,loss of appetite and weight gain) : the occurrence rates of increased appetite and body mass gain of combined Olanzapine group were higher than those of combined Quetiapine group,and the differences had statistical significance( P 0. 05); however,the other items had no obvious differences. Conclusions: For the patients with depression combined with anxiety disorder,Paroxetine combined with Quetiapine or Olanzapine both has a faster effect,fewer adverse reactions,and good compliance; so the two ways are all rather good synergistic strategies. For the obese,the treatment of combination of Quetiapine is safer.