Clinical and pathological analysis of HBV-associated glomerulonephritis with 82 patients

Objective To investigate the clinical and pathological features of hepatits B virus associated glomerulonephritis(HBV-GN).Method Clinical and pathological features were analyzed and correlated in 82 cases with renal biopsy-confirmed HBV-GN in our hospital from Jan 2000 to Oct 2012.Results 48 males and 34 females aged from 6 to 70 years old were included in this study.82 patients were with HBV-GN diagnosed by renal biopsy.Syndrome was the most common clinical manifestation(51cases),followed by nephrotic syndrome(20 cases) and asymptomatic hematuria with or without the presence of proteinuria(7cases),chronic renal failure(4cases).In this study,renal biopsy data showed that membranous nephropathy(MN) was the most frequent type with 50 cases(60.96%),followed by membranoproliferative glomerulonephritis(MPGN) with 11cases(13.41%) and mesangial proliferative glomerulonephritis(MsPGN) 7 cases(8.54%),then IgA nephropathy(IgAN)with 6 cases(7.31%),Sclerosing glomerulonephritis(SGN)with 5 cases(6.10%) and focal segmental glomerulosclerosis(FSGS) 2 cases(3.66%).Analysis of correlation indicated that serum HBV-DNA correlated positively with 24 hours urine protein ration(24hupr) and cystatin c(CysC).Conclusion The clinical manifestations of HBV-GN was diversity,the most in the common nephrotic syndrome.The pathological type was most of MN,followed by MPGN.