Clinical and pathological analysis on hepatitis B virus-associated glomeru lonephritis in children

Objective To investigate the clinical and pathological characteristics of hepatits B virus-associatedglomerulonephritis(HBV-GN)in children.Method The clinical manifestation and pathological findings of 36 children with HBV-GN in our hospital from March 1984 to March 2007 were investigated retrospectively.Results Among 36 children with HBV-GN diagnosed by renal biopsy,nephrotic syndrome was the the most common clinical manifestation(33 cases,91.7%),followed by glomerular nephritis(3cases,8.3%).Membranous nephropathy(MN) was the most common pathological change(21 cases,58.3%),followed by mesangial proliferative glomerulosclerosis(MsPGN,27.8 %),membranoproliferative nephritis (MPGN,8.3%) and endocapillary proliferative glomerulonephritis(EnPGN,5.6%).In the patients with HBV-GN,immunofluorescence microscope(IF) result showed variety immune complex deposits.HBV markers of renal tissues were positive in 27 cases,with the rate of 75.0%.Conclusion HBV-GN often happens in school age children,and HBV-GN is more common in male than in female.The clinical manifestation and pathological findings are diversification,and the predominantly presenting features are nephrotic syndrome and membraneous nephropathy.Once the marker of HBV is positive and kidney function is abnormal in children,renal biopsy should be carried out as soon as possible.