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2001•Journal of Zhenjiang Medical CollegeRequires access

The Clinical Significance of the Expression of CD44v5 in Tumor Tissue of Patients with Gastric Cancer

Yuan Jing-lun

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Abstract

Objective:To study the expression of CD44v5 in tumor tissue of patients with gastric carcinoma and its clinical significance.Methods:Tissue expression of CD44v5 in gastric carcinomas was investigated by immunohistochemistry.Results:The expression of CD44v5 could be detected in 69.8% of tumor tissue,but could not be detected in adjacent normal gastric mucosa.Significant correlations were noted between CD44v5 expression and depth of invasion,and lymph node metastasis.The presence of CD44v5 protein was correlated with the lymph node involvement rate.Conclusion:CD44v5 in tumor tissue may be useful as a metastatic marker.It may be of important clinical value in the diagnosis of metastasis and judgement of development for the patients with gastric cancer to analyse the expression of CD44v5 in tumor tissue by immunohistochemistry.

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Objective:To study the expression of CD44v5 in tumor tissue of patients with gastric carcinoma and its clinical significance.Methods:Tissue expression of CD44v5 in gastric carcinomas was investigated by immunohistochemistry.Results:The expression of CD44v5 could be detected in 69.8% of tumor tissue,but could not be detected in adjacent normal gastric mucosa.Significant correlations were noted between CD44v5 expression and depth of invasion,and lymph node metastasis.The presence of CD44v5 protein was correlated with the lymph node involvement rate.Conclusion:CD44v5 in tumor tissue may be useful as a metastatic marker.It may be of important clinical value in the diagnosis of metastasis and judgement of development for the patients with gastric cancer to analyse the expression of CD44v5 in tumor tissue by immunohistochemistry.

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Available abstract

Objective:To study the expression of CD44v5 in tumor tissue of patients with gastric carcinoma and its clinical significance.Methods:Tissue expression of CD44v5 in gastric carcinomas was investigated by immunohistochemistry.Results:The expression of CD44v5 could be detected in 69.8% of tumor tissue,but could not be detected in adjacent normal gastric mucosa.Significant correlations were noted between CD44v5 expression and depth of invasion,and lymph node metastasis.The presence of CD44v5 protein was correlated with the lymph node involvement rate.Conclusion:CD44v5 in tumor tissue may be useful as a metastatic marker.It may be of important clinical value in the diagnosis of metastasis and judgement of development for the patients with gastric cancer to analyse the expression of CD44v5 in tumor tissue by immunohistochemistry.

Key concepts: Immunohistochemistry, Pathology, Metastasis, Cancer, Clinical significance, Medicine, Lymph node, Lymph node metastasis

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