Expression of COX-2 in ovarian epithelial carcinomas and its correlation with expression of MUC-1 protein

Objective To investigate expression of COX-2 and MUC-1 in ovarian epithelial carcinoma and their significance.Methods Two monoclonal antibodies,anti-COX-2 and anti-MUC-1 were used in immunohistochemical reaction to measure COX-2 and MUC-1 in paraffin section of 39 ovarian epithelial carcinoma,11 ovarian tumor and 10 normal controls.And clinical pathological sections of ovarian epithelial-carcinoma were also examined.Results There was no expression of COX-2 and MUC-1 in normal controls,but over expression in some ovarian epithelial carcinoma.COX-2 over expression were uncorrelated with the clinical stages and histodifferentiation and pathological type of ovarian epithelial carcinoma(P0.05),MUC-1 over expression were correlated with the clinical stages and histodifferentiation and pathological type of ovarian epithelial carcinoma.The over expression of COX-2 and MUC-1 were also correlated with prognosis of ovarian epithelial carcinoma(P0.05).In ovarian epithelial carcinoma,over expression of COX-2 was correlated well with MUC-1(P=0.012).Conclusions COX-2 and MUC-1 may be correlated with the occurrence of ovarian epithelial carcinoma,with advanced and metastasis.The measurement of COX-2 and MUC-1 can be used to evaluate the prognosis of ovarian epithelial carcinoma and to assist in chemotherapy.