Clinical Correlation of COX-2 and MUC1 Protein Expression in Ovarian Epithelial Carcinoma

Objective: To investigate correlation of cox-2 and mucl expression in ovarian epithelial carcinoma. Methods: Two monoclonal antibodies, anti-cox-2 and anti-mud and were used in immunohistochemical reaction to measure Cox-2 and mucl paraffin section of 39 ovarian epithelial carcinoma, 11 ovarian tumor and 10 normal controls. And clinical pathological sections of ovarian epithelial-carcinoma were also examined. Results: (1)There was no expression of COX-2 and MUC1 in normal controls, but overexpression in some ovarian epithelial carcinoma. (2) COX-2 overexpression was not correlated with the clinical stages and histo-differentiation and pathological type of ovarian epithelial carcinoma (P0.05), MUC1 overexpression was correlated with the clinical stages and histo-differentiation and pathological type of ovarian epithelial carcinoma .(2)The overexpression of COX-2 and MUC1 was also correlated with prognosis of ovarian epithelial carcinoma (P0.05). Conclusion: COX-2 and MUC1 may be correlated with the occurrence of ovarian epithelial carcinoma, with advanced and metastasis also. The measurement of COX-2 and MUC1 could be used to evaluate the prognosis of ovarian epithelial carcinoma and to assist in chemotherapy.