2009•Zhongguo fuyou baojianRequires access
Expression and clinical significance of Cyclooxygenase-2 in epithelial ovarian cancer
Gao Ha, Gao Fen
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Abstract
Objective:To investigate the expression of cyclooxygenase-2(COX-2) in epithelial ovarian cancer tissue,and understand its clinical significance.Methods:The expression of COX-2 were examined in epithelial ovarian cancer,benign ovarian neoplasm and normal tissue controls by immunohistochemical staining.Then the relationship between the expression of COX-2 in human ovarian epithelial cancer and its clinical pathologic parameters was aggregate analyzed by SPSS 13.0 software.Results:The expression of COX-2 in epithelial ovarian cancer 78%(39/50) was higher than that in normal ovarian tissue 10%(1/10),the difference was statistically significance(P0.01).The expression of COX-2 was correlated with histological differentiation,lymphnode metastasis and prognosis(P0.05),but not with age,clinical stage and histological types(P0.05).Conclusion:The expression of COX-2 in epithelial ovarian cancer is significantly higher than that in normal ovarian tissue and benign ovarian neoplasm,it plays a key role in progression and metastasis of epithelial ovarian cancer.The over expression of COX-2 may serve as an useful marker for assessment of the biological behavior of epithelial ovarian cancer and may helpful for assessing the malignancy prognosis.