ScholarLens Back to search
2008•Hebei Yike Daxue xuebaoRequires access

EFFECT OF THALIDOMIDE ON THE EXPRESSION OF SERUM TNF-α IN RATS WITH COLLAGEN INDUCED ARTHRITIS

Jie Fu

Open publisher page 0 citations

Abstract

Objective To explore the effect of thalidomide on the expression of serum TNF-α in rats with collagen induced arthritis(CIA).MethodsArthritis animal model was induced by collagen.Seventy-six healthy male Wistar rats were divided into three groups,the control group,the model group and the thalidomide treatment group.Compare the relationship between serum TNF-α concentration and the paw thickness of model rats to investigate the possible mechanism of RA and the treatment effect of thalidomide on CIA rats.ResultsThe more serious the arthritis is,the higher concentration of the serum TNF-α.There is a markedly positive correlation between arthritis and TNF-α concentration.Thalidomide can reduce the serum TNF-α concentration and meliorate the arthritis state of rats with CIA.ConclusionThalidomide can meliorate the symptoms of arthritis through reducing the serum TNF-α concentration,it is hopeful to apply thalidomide in the treatment of RA patients.

About this research paper

What this paper is about

Objective To explore the effect of thalidomide on the expression of serum TNF-α in rats with collagen induced arthritis(CIA).MethodsArthritis animal model was induced by collagen.Seventy-six healthy male Wistar rats were divided into three groups,the control group,the model group and the thalidomide treatment group.Compare the relationship between serum TNF-α concentration and the paw thickness of model rats to investigate the possible mechanism of RA and the treatment effect of thalidomide on CIA rats.ResultsThe more serious the arthritis is,the higher concentration of the serum TNF-α.There is a markedly positive correlation between arthritis and TNF-α concentration.Thalidomide can reduce the serum TNF-α concentration and meliorate the arthritis state of rats with CIA.ConclusionThalidomide can meliorate the symptoms of arthritis through reducing the serum TNF-α concentration,it is hopeful to apply thalidomide in the treatment of RA patients.

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Objective To explore the effect of thalidomide on the expression of serum TNF-α in rats with collagen induced arthritis(CIA).MethodsArthritis animal model was induced by collagen.Seventy-six healthy male Wistar rats were divided into three groups,the control group,the model group and the thalidomide treatment group.Compare the relationship between serum TNF-α concentration and the paw thickness of model rats to investigate the possible mechanism of RA and the treatment effect of thalidomide on CIA rats.ResultsThe more serious the arthritis is,the higher concentration of the serum TNF-α.There is a markedly positive correlation between arthritis and TNF-α concentration.Thalidomide can reduce the serum TNF-α concentration and meliorate the arthritis state of rats with CIA.ConclusionThalidomide can meliorate the symptoms of arthritis through reducing the serum TNF-α concentration,it is hopeful to apply thalidomide in the treatment of RA patients.

Key concepts: Thalidomide, Arthritis, Tumor necrosis factor alpha, Medicine, Collagen-induced arthritis, Serum concentration, Internal medicine, Endocrinology

Related papers

Related paper 1Related paper 2Related paper 3
Back to paper searchBrowse research topicsOriginal source
EFFECT OF THALIDOMIDE ON THE EXPRESSION OF SERUM TNF-α IN RATS WITH COLLAGEN INDUCED ARTHRITIS — Research Paper | ScholarLens