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Effect of Guizhishaoyaozhimu Decoction on Serum Activity of TNF-α,IL-1β in Rats with CII-Induced Arthritis

Xiaojun Chen

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Abstract

Objective To investigate the therapeutic effect and mechanism of rheumatoid arthritis.Methods Arthritis of rat induced by type Ⅱ collage was used as rheumatoid arthritis model.Selling of ankles of rats was measured and arthritis index was assessed to observe the therapeutic effect of Guizhishaoyaozhimu(GZSY)Decoction.The activity of TNF-αin serum was investigated with ELISA method.And the activity of IL-1β in serum was investigated by thymocyte cell proliferation.Results Compared with that of model group,the swelling of GZSY group and arthritis index were relieved significantly.The activity of TNF-αand IL-1β in model group were significant higher than those in normal group.But in GZSY group,the activity of those cytokines was decreased significantly.Conclusion GZSY has an effect on immune arthritis induced by typeⅡ collage,and the decrease of TNF-αand IL-1βin serum may be one of its mechanisms.

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What this paper is about

Objective To investigate the therapeutic effect and mechanism of rheumatoid arthritis.Methods Arthritis of rat induced by type Ⅱ collage was used as rheumatoid arthritis model.Selling of ankles of rats was measured and arthritis index was assessed to observe the therapeutic effect of Guizhishaoyaozhimu(GZSY)Decoction.The activity of TNF-αin serum was investigated with ELISA method.And the activity of IL-1β in serum was investigated by thymocyte cell proliferation.Results Compared with that of model group,the swelling of GZSY group and arthritis index were relieved significantly.The activity of TNF-αand IL-1β in model group were significant higher than those in normal group.But in GZSY group,the activity of those cytokines was decreased significantly.Conclusion GZSY has an effect on immune arthritis induced by typeⅡ collage,and the decrease of TNF-αand IL-1βin serum may be one of its mechanisms.

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Available abstract

Objective To investigate the therapeutic effect and mechanism of rheumatoid arthritis.Methods Arthritis of rat induced by type Ⅱ collage was used as rheumatoid arthritis model.Selling of ankles of rats was measured and arthritis index was assessed to observe the therapeutic effect of Guizhishaoyaozhimu(GZSY)Decoction.The activity of TNF-αin serum was investigated with ELISA method.And the activity of IL-1β in serum was investigated by thymocyte cell proliferation.Results Compared with that of model group,the swelling of GZSY group and arthritis index were relieved significantly.The activity of TNF-αand IL-1β in model group were significant higher than those in normal group.But in GZSY group,the activity of those cytokines was decreased significantly.Conclusion GZSY has an effect on immune arthritis induced by typeⅡ collage,and the decrease of TNF-αand IL-1βin serum may be one of its mechanisms.

Key concepts: Rheumatoid arthritis, Decoction, Medicine, Arthritis, Therapeutic effect, Tumor necrosis factor alpha, Immune system, Internal medicine

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Effect of Guizhishaoyaozhimu Decoction on Serum Activity of TNF-α,IL-1β in Rats with CII-Induced Arthritis — Research Paper | ScholarLens