Analysis of drug resistance among 86 patients with retreated pulmonary tuberculosis

Objective To investigate the features of drug resistance in the patients with retreated pulmonary tuberculosis. Methods Single drug resistance, Poly-drug resistance, and multidrug resistance, treatment rate and adverse reactions in 86 patients were analyzed retrospectively. Results 100% patients showed resistance to any drug. 91.9% patients were poly-drug resistance and 65.1% patients were multidrug resistant. The sequence of the first-line anti-tuberculosis drug usage was HR SE. Levofloxacin had highest resistance (37.21%) in the second line drugs. The negative conversion rate of phlegm germ was 60.46% after treatment for 3 months. The 40～60 year old patients had highest rate of resistance to drugs (68.96%). The mainly adverse reactions were allergy (54.65%) and abnormal liver function (8.14%). Conclusion The patients with retreated pulmonary tuberculosis had higher rate of drug resistance, especially the old patients. We should pay more attention to TB culture and drug sensitivity test, and choose treatment according to the test results.