Clinical analysis of secondary drug resistance in patients with retreated pulmonary tuberculosis

Objective To investigate the features of drug resistance in the patients with retreated pulmonary tuberculosis with common antituberculotics. Methods The sensibility of tubercule bacillus to the antituberculotics was tested in 285 patients with retreated pulmonary tuberculosis.Results Of 285 patients,118 cases(41.4%) had a drug resistance to isoniazid,71 cases(24.9%) had a drug resistance to rifampicinthe,134 cases(47.0%) had a drug resistance to streptomycin,62 cases(21.8%) had a drug resistance to pyrazinamide,87 cases(30.5%) had a drug resistance to ethambutol.The percentage of having drug resistance to 2 to 3 first-line antituberculotics was more than that to 4 to 5 drugs resistance (60.3% vs.19.7%)(P0.01).Conclusion The patients with retreated pulmonary tuberculosis are easy to produce drug resistance to the first-line antituberculotics and commonly need a combined use of the second-line antituberculotics.