Analysis of Drug-Resistance in 1067 Patients with Tuberculosis

Objective To explore the situation of drug resistance in tuberculosis( TB) patients,and to provide the references for formulating a reasonable therapy. Methods A clinical data of 1067 TB patients and their drug susceptibility test results were analyzed. Results Among 1 067 cases,there were 792 sensitive cases,275( 25. 77%) drug resistant cases,including 98( 9. 18%) of mono-resistance,48( 4. 50%) of poly-resistance,117( 10. 97%) of multidrug-resistance,12(1.12%) of extensively drug-resistance.The drug resistance rate of re-treatment patients was significantly higher than that of first-treatment patients( P 0. 05). There was no significant difference in the drug resistance rate between patients with positive HIV antibody and patients with negative HIV antibody( P 0. 05). 67. 64% of the drug resistant patients had isoniazid resistance,65. 09% of the drug resistant patients had rifampicin resistance. The total rate of drug resistance of ofloxacin was 9. 18%,and mono-resistance rate was 2. 34%. Multidrug-resistance accounted for 42. 55% of patients with drug resistance,the resistances to isoniazid and rifampicin were the most common. Conclusion The patients in the tuberculosis special hospital have a higher mycobacterium tuberculosis resistance rate and various drug resistance profiles,the resistances to isoniazid and rifampicin are the most common.