mTOR and PTEN in Cervical Squamous Cell Carcinoma and Its Significance

Objective The expression of mTOR and PTEN in cervical cancer tissue and their function on occurrence and progress of cervical squamous cancer.Methods The expression of mTOR and PTEN in 70 specimens of cervical squamous carcinoma and 20 specimens of normal cervical epithelium were detected by SP immunohistochemistry.Their correlations were analyzed.Results The expression of mTOR on cervical cancer was significantly higher than normal cervical(P0.01).The expression of mTOR was correlated with clinical stages(P0.01),but there was no difference with regard to pathological grades and lymph node metastasis(P0.05).The PTEN is lower expressed in cervical cancer tissue than in normal cervical tissue(P0.01).The PTEN expression has no relationship with staging,grading and lymphatic metastasis of cervical cancer.The expression of mTOR protein was positively correlated to the expression of PTEN protein.(P0.01).Conclusion The mTOR and PTEN protein associate with the occurrence of cervical cancer.