Clinical observation of dezocine combined with flurbiprofen for postoperative analgesia after abdominal surgeries:a prospective study

Objective To investigate the effects of dezocine combined with flurbiprofen for postoperative analgesia after abdominal surgeries.Methods This was a multi-center,prospective, single-blind and controlled clinical study.Two hundred and sixteen patients scheduled for selective upper-abdominal operation were randomly divided into dezocine group(group D) and sufentanil group (group S).Thirty minutes before the end of operation,patients in group D were given 5 mg dezocine and 50 mg flurbiprofen,and then an intravenous pump containing 25 mg dezocine and 250 mg flurbiprofen in a volume of 100 ml was administered at the speed of 2 ml/h for 48 h after operation. For patients in group S,3μg sufentanil were administered before the end of operation and then 3μg/kg sufentanil for continuous infusion.Visual analogue score(VAS) during both silence and 90 turn over situation,Ramsay score,and adverse effects at 1,4,8,12,24,36,48 h after the operation were recorded respectively.Results Compared with group S,patients in group D showed no significant difference in the Ramsay score and VAS pain during silence,but a significant decrease in VAS pain under turn-over was observed(P0.05).Less perspiration,nausea and chill were observed in group D than group S(P0.05).Also,there was no shivering occurred in group D. Conclusion Administration of dezocine combined with flurbiprofen has a preferable therapeutic effect for post-operative movement pain and less adverse effect as compared to sufentanil alone.