Clinical study on dezocine and sufentanil for postoperative analgesia in upper-abdominal surgery or hip replacement surgery

Objective To investigate the effect of dezocine combined with sufentanil on postoperative analgesia and side effects in the upper-abdominal surgery and hip replacement surgery,and explore the potential mechanisms.Methods One hundred patients scheduled for selective upper-abdominal operation and hip replacement surgery were randomly divided into group dezocine(group D),dezocine 0.3 mg/kg combined with sufentanil 1 μg/kg group(group DS1),dezocine 0.3 mg/kg combined with sufentanil 1.5 μg/kg group(group DS2) and dezocine 0.3 mg/kg combined with sufentanil 2 μg/kg group(group DS3).Analgesia was maintained by remifentanil 6-8 μg·kg-1·h-1 under total intravenous anesthesia.Patients were administered 5μg sufentanil during sewing the skin.Visual Analogue Score(VAS)of both silence and 90° turn over situation,Ramsay score,and adverse effects at 1 h(T1),4 h(T2),8 h(T3),12 h(T4),24 h(T5),36 h(T6),48 h(T7)after the operation were recorded respectively.Results The total amount of sufentanil and dezocine of group DS1 group showed a significant higher than the other three groups(P0.05).The VAS in silence of group DS1 were higher than group DS3 at T1-T3(P0.05).There was no significant difference in VAS under 90° turn over situation.The side effect of group DS3 were higher than the other three groups(P0.05).Conclusion Dezocine combined with sufentanil for postoperative patient-controlled intravenous analgesia(PCIA)is effective and safe in patients undergoing upper-abdominal surgery and hip replacement surgery,and while dezocine 0.3 mg/kg combined with sufentanil 1.5 μg/kg,it has the best effect of postoperative analgesia and least side effects.