Effects of Didang Decoction on Expression of Intercellular Adhesion Molecular-1 in Diabetic Nephropathy Rats

Objective:To investigate influence of Didang decoction on the low extremity vascular disease of STZ-induced diabetic rats.Method: After being injected streptozotocin(STZ) into the caudal vein and fed with the high fat diet,diabetes model rats were divided into normal control group,model control group,Didang decoction group,and the rosiglitazone group.After continuous stomach perfusion administration for 12 weeks,the change of blood glucose,total urinary protein in 24 h,serum creatinine were detected with correlative methods,and the expression of intercellular adhesion molecule-1(ICAM-1) in kidney were examined by inmunohistochemical technique.Result: Compared with normal control group,the expression of ICAM-1 in model control group is significantly increased.Compared with model control group,the expression of ICAM-1 is decreased in Didang decoction group,and rosiglitazone group.Conclusion: Didang decoction can restrain expressions of ICAM-1 on kidney,maybe one of the possible mechanisms.