Expression and relationship between PTEN and EGFR in gastric carcinoma.

Objective:To investigate expression of PTEN and EGFR in gastric carcinoma and to explore its relationship with the genesis and development of gastric carcinoma and its relationship with clinicopathological parameters. Methods:Immunohistochemistry(S-P) was used to detect the expression of PTEN and EGFR protein in 105 case of gastric carcinoma tissues and their adjacent normal gastric tissues. Results:In the normal gastric tissue,the positive rate of PTEN protein(92.3%) were higher than those in gastric cancer tissue(56.19%) . The over expression of EGFR in gastric carcinoma was higher than that in normal gastric tissues(7.62%) ( P 0. 01) . Their expression were unrelated with gender and age of gastric carcinoma(P0.05) ,but closely correlated with levels of histological differentiation and clinical pathology stages. Conclusions:The PTEN protein expression flaw and over expression of EGFR which may play certain role in the genesis and development of gastric carcinoma and closely related the degree of differentiation,depth of invasion,lymph node metastasis and clinical stages. There was negative trend between PTEN expression and EGFR in gastric carcinoma.