Relationship Between Adiponectin and Type 2 Diabetes

In order to study the effect of plasma adiponectin on type 2 diabetes patients,the correlation between plasma adiponectin,serum glucose,insulin and plasma lipid of the patients with type 2 diabetes was analyzed.32 subjects with normal glucose,105 with type 2 diabetes,including 53 subjects without obesity(BMI25 kg/m2) and 52 with obesity(BMI≥25kg/m2) were involred into this study.The fasting plasma adiponectin,serum glucose,insulin and plasma lipid were measured by RIA.The results showed that the mean plasma adiponectin in normal,non-obesity and obesity group was 9.46±0.89mg/L,5.83±1.06mg/L and 3.17±0.56mg/L,respectively.The plasma adiponectin levels in the type 2 diabetes group were significantly lower than that in normal group(P0.05),especially in obesity group.The adiponectin level was significantly correlated with serum glucose and triglyceride,r value was-0.59 and-0.76,respectively.Adiponectin may be a kind of protective factor.It takes part in the pathogenesis of type 2 diabetes,and is close correlated with insulin resistance.The plasma adiponectin might be an effective index in the early diagnosis,prevention and treatment of type 2 diabetes.