Relationship between adiponectin,leptin and abnormality of glucose,lipids metabolism in aged type 2 diabetes patients

【Objective】To investigate the level of human serum adiponectin and the relationship between serum adiponectin and leptin as well as glucose,lipids profiles in aged type 2 diabetes with or without obesity.【Methods】A total of 140 patients resident in Tinjin were recruited.All data were taken at the same time by taking history and physical examination followed by collection of fasting blood sample for analysis.【Results】The levels of the serum adiponectin showed significant difference between the aged type 2 diabetes and the normal control.As to the aged type 2 diabetes with obese,the level of adiponectin were lower than that in control.The level of adiponectin showed no difference between the aged and the young.Adiponectin level was inverted correlation with waist size(WS),fasting and 1 h,2 h postprandial glucose,glucose intolerance in OGTT,insulin resistance index(HOMA-IR),leptin.The adiponectin levels were positively correlated with HDL.In step regression analysis,WS,leptin and fasting glucose remained significantly related with adiponectin concentrations after adjustment for all the other variables in this study.【Conclusions】The adiponectin level in the aged people with type 2 diabetes are lower than nondiabetic.Our study shows that there is a mutual modulatory mechanism among the obesity,type 2 diabetes,leptin,insulin and adiponectin.