Clinical analysis of distribution and resistance of pathogenic bacteria in senile patients of lower respiratory tract infection

Objective: To analysis distribution and resistance of Pathogenic Bacteria in senile patients from lower respiratory tract infection and provide reference for rational use of antibiotics in clinics.Methods: Phlegm specimens were collected from lower respiratory tract in elder patients from January 2007 to December 2011 in our institution.K-B test was used to determine drug susceptibility and the results were read based on 2009 Clinical and Laboratory Standards Institute(CLSI).Results: Among 633 isolated strains,gram-negative bacteria,gram-positive cocci and fungi were 68.25%,21.32% and 10.4%,respectively.The top 5 of isolated bacteria were Escherichia coli,Klebsiella pneumoniae,Pseudomonas aeruginosa,Staphylococcus aureus and Acinetobacter baumannii.MRSA accounted for 75.7% of Staphylococcus aureus and resistant gram-positive cocii to Vancomycin,Teicoplanin and Linezolid were not found.The resistant rate of gram-negative bacteria was less than 35% to carbapenems,and more than 84% to Ampicillin and third generation Cephalosporins.Pseudomonas aeruginisa and Acinetobacter baumannii had higher resistant rate to many antibiotics,their resistant rate were 14.7%-96.0%.Acinetobacter was more susceptible to carbapenems,cefoperazone / sulbactam and amikacin.The drug-resistant spectrum of Klebsiella pneumoniae and Escherichia coli was similar.Conclusion: The bacteria from lower respiratory tract infection in elderly patients were distributed extensively and there was severe resistance to antimicrobials.It is necessary to monitor bacteria,using rationally antibiotics and curbing down their drug-resistence.