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Effects of Piracetam on Superoxide Dismutase Activity and Malonaldehyde Content in Brain Tissues of D-galactose-induced Aging Rats

Xiao Xiu-lian

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Abstract

OBJECTIVE: To explore the effects of piracetam on superoxide dismutase(SOD) activity and malonaldehyde(MDA) content in brain tissues of D-galactose-induced ageing rats.METHODS: 30 SD rats were randomized to one of the 3 groups: blank control group(NS),model group(D-galactose+NS) and piracetam group(D-galactose+piracetam 432 mg·kg-1·d-1).All the rats were put to death at 90 days after medication,and the SOD activity and MDA content in brain tissues were determined.RESULTS: As compared with the blank control,the SOD activity decreased(P0.01) but MDA content increased(P0.05) in model group.As compared with the model group,the SOD activity increased (P0.05) but MDA content decreased(P0.01) in piracetam group.CONCLUSION: The antiaging effect of piracetam might be achieved by its action of enhancing SOD activity and decreasing MDA content.

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OBJECTIVE: To explore the effects of piracetam on superoxide dismutase(SOD) activity and malonaldehyde(MDA) content in brain tissues of D-galactose-induced ageing rats.METHODS: 30 SD rats were randomized to one of the 3 groups: blank control group(NS),model group(D-galactose+NS) and piracetam group(D-galactose+piracetam 432 mg·kg-1·d-1).All the rats were put to death at 90 days after medication,and the SOD activity and MDA content in brain tissues were determined.RESULTS: As compared with the blank control,the SOD activity decreased(P0.01) but MDA content increased(P0.05) in model group.As compared with the model group,the SOD activity increased (P0.05) but MDA content decreased(P0.01) in piracetam group.CONCLUSION: The antiaging effect of piracetam might be achieved by its action of enhancing SOD activity and decreasing MDA content.

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Available abstract

OBJECTIVE: To explore the effects of piracetam on superoxide dismutase(SOD) activity and malonaldehyde(MDA) content in brain tissues of D-galactose-induced ageing rats.METHODS: 30 SD rats were randomized to one of the 3 groups: blank control group(NS),model group(D-galactose+NS) and piracetam group(D-galactose+piracetam 432 mg·kg-1·d-1).All the rats were put to death at 90 days after medication,and the SOD activity and MDA content in brain tissues were determined.RESULTS: As compared with the blank control,the SOD activity decreased(P0.01) but MDA content increased(P0.05) in model group.As compared with the model group,the SOD activity increased (P0.05) but MDA content decreased(P0.01) in piracetam group.CONCLUSION: The antiaging effect of piracetam might be achieved by its action of enhancing SOD activity and decreasing MDA content.

Key concepts: Piracetam, Superoxide dismutase, Chemistry, Galactose, Dismutase, Pharmacology, Endocrinology, Internal medicine

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Effects of Piracetam on Superoxide Dismutase Activity and Malonaldehyde Content in Brain Tissues of D-galactose-induced Aging Rats — Research Paper | ScholarLens