The comparison between GP and NP regimens for treatment of advanced non-small cell lung cancer

Objective To compare the efficacy and toxicity between GP(gemcitabine +cisplatin) regimen and NP(vinorelbine + cisplatin) regimen in the treatment of advanced non-small cell lung cancer(NSCLC).Methods Fifty-six cases of advanced NSCLC were enrolled:29 cases were treated with GP regimen(GEM 1.0-1.2 g/m2,ivgtt d1 and d8,DDP 25 mg/m2,ivgtt d1-3),27 cases were treated with NP regimen(NVB 25 mg/m2,iv d1 and d8,DDP 25 mg/m2,ivgtt d1-3).The treatment in two groups was repeated every three weeks and the efficacy was evaluated after two cycles.Results For the cases treated with GP regimen,the overall response rate was 44.8%,the overall response rate in the cases treated with NP regimen was 40.7%,there was no significant difference between two groups(P 0.05).Major toxicity was myelosuppression.The leukocytopenia was more severe in NP regimen group than in GP regimen group(85.2% versus 51.7%,P 0.05).The thrombocytopenia was more severe in GP regimen group than in NP regimen group(82.8% versus 22.2%,P 0.05).The phlebitis was more severe in NP regimen group than in GP regimen group(29.6% versus 6.9%).There was significant difference between the two groups.Conclusion Both GP regimen and NP regimen show obvious efficacy in treatment of advanced NSCLC.The side effects of the two regimens are different but all are tolerable.