Comparison of short-term efficacy between the NP and GP regimens in the treatment of locally advanced non-small cell lung cancer

Objective:To compare the short-term therapeutic efficacy,toxicity and side reactions between navelbine plus cisplatin(NP regimen) and gemcitabine plus cisplatin(GP regimen) in the treatment of locally advanced non-small cell lung cancer(NSCLC).Methods:Forty-five patients with cytologically and pathologically confirmed NSCLC were divided into two groups.Twenty-three cases in the A group received NP regimen chemotherapy.Twenty-two cases in the B group received GP regimen chemotherapy.Both regimens were repeated after a cycle of 21 days.Results:Response rates were 47.8%(A group) and 54.5%(B group) respectively for NP and GP regimens,without statistical difference between the two groups(P0.05).Myelosuppression was the major dose-limiting toxicity in both groups.Gastrointestinal reaction and local phlebitis were also observed.The rates of grade Ⅲ-Ⅳ leukopemia were 34.8%(A group) and 31.8%(B group),the rates of grade Ⅲ-Ⅳ thrombocytopenia were 4.3%(A group) and 9.1%(B group),without statistical difference between the two groups(P0.05).Local rates of phlebitis were 34.8%(A group) and 0(B group),with statistical difference between the two groups(P0.05).Conclusion:The therapeutic effectiveness of NP regimen is similar to that of GP regimen.The toxic reactions were tolerable.