The application of different chemotherapy regimens in non-small cell lung cancer

Objective To explore the effect of GP regimen(Cisplatin combined with Gemcitabine) and NP regimen(Cisplatin combined with Navelbine) in treatment of non-small cell lung cancer.Methods The data of 86 cases with non-small cell lung cancer were retrospectively analyzed with 45 patients in GP group and 41 patients in NP group.Clinical effect,sur vival time and toxic side effects were compared between two groups.Results The effective rates in GP group and NP group were 44.4% and 36.6% respectively,the difference was not statistically significant(P 0.05);The difference of median survival time between two groups was not statistically significant(9.7 months vs 8.8 months,P 0.05);Hematological toxicity was the major toxic side effect in two groups.The occurrence rate of grade Ⅲ/Ⅳ thrombocytopenia in GP group was much higher than that in NP group,the difference was statistically significant(P 0.05),but the incidence rate of grade Ⅲ/Ⅳ leucopenia in GP group was much lower than that in NP group,the difference was statistically significant(P 0.05).Conclusion GP regimen and NP regimen for treatment of non-small cell lung cancer are equally effective and well tolerat ed.Patients can choose the rational regimen according to the conditions.