The Effect of Busui Shengxue Granule on the Expression of NF-κΒ/p65 in CAA Patients' Bone Marrow

Objective:To investigate the effect of Busui Shengxue granule on the expression level of phosphorylation of the NF-κΒ in marrow mononuclear cell of the CAA patients.Method: Collect 40 CAA patients,which were treated by Busui Shengxue granule for 6 months and 30 healthy persons,and observe the expression level of phosphorylation of NF-κΒ/p65 in marrow mononuclear cell of CAA patients.Results: The expression level of NF-κΒ/p65 in marrow mononuclear cell of CAA patients was lower than that in normal group(P0.05).It rose up after having been treated by Busui Shengxue granule.This is a significant difference to the prior treatment group(P0.05).Conclusion: There is an abnormal low expression level of phosphorylation of the NF-κΒ/p65 in marrow mononuclear cell of CAA patients.The abnormal expressions of NF-κΒ/p65 may participate in the process of the nosogenesis of CAA.Accordingly,it may cause an abnormal transduction of the sign of medullary hematopoiesis.The Busui Shengxue granule may make a good change to the hemopoietic microenvironment by adjusting the expression level of phosphorylation of the NF-κΒ/p65 in marrow mononuclear cells.