The Effect of Busui Shengxue Granule on MEK Expressions of Bone Marrow Mononuclear Cells of Patients with Chronic Aplastic Anemia

Objective: To investigate Busui Shengxue Granule in patients with chronic aplastic anemia(CAA) in bone marrow mononuclear cells mitogen-activated protein kinase(MEK) expression and its mechanism.Methods: Western blotting(Western-blot) was detected by CAA,the expression of normal levels of bone marrow stromal cells MEK.Results: CAA bone marrow mononuclear cells of patients with MEK expression were lower than that in the normal group(P0.05),by Busui Shengxue Granule after treatment,MEK expression levels increased compared with pre treatment,which had a significant difference(P0.05).Conclusions: CAA bone marrow stromal cells showed low levels of MEK expression.it may be involved in the process of the pathogenesis of CAA;Medicine Busui Shengxue particles may be by regulating the expression levels of MEK and anti-apoptotic role for MEK,thus affecting the bone marrow signal pathway to promote bone marrow function.