Experimental Study on the Effect of Soluble Granules of Busui Shengxue on ICAM-1 and VCAM-1 of Bone Marrow Stromal Cell of Chronic Aplastic Anemia

Objective To explore the machanism of Soluble Granules of Busui Shengxue on chronic aplastic anemia (CAA). Methods The patients were divided into Soluble Granules of Busui Shengxue group and AABET group in random. We analyzed the expression of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) of bone marrow stromal cell (BMSC) before treatment and after treatment by using technology of immunofluorescence assay. Result The level of ICAM-1 and VCAM-1 of the two groups was obviously lower than the control group before treatment (P0.001), and the level of them have been raised on the different degree after treatment. In increasing ICAM-1, Soluble Granules of Busui Shengxue group is better than control group. Yangxu is better than yinxu. Conclusion Expression of ICAM-1 and VCAM-1 of BMSC on CAA is abnormal. Soluble Granules of Busui Shengxue can increase the expression of ICAM-1 and VCAM-1, consequently promote the marrow to produce the blood. Further to prove the theory of easy to treat yangxu and difficult to treat yinxu.