2001•Integrated Traditional Chinese and Western Medicine In Practice of Critical Care MedicineRequires access
The experiment study on the treatment to the apoptosis of hematopoietic stem cell of chronic aplastic anemia with the soluble granules of Busui Shengxue(补髓生血冲剂)
Jing Tian
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Abstract
Objective:To observe the mechanism of the treatment to chronic aplastic anemia(CAA) with the soluble granules of Busui Shengxue(补髓生血冲剂).Methods:The apoptosis of hematopoietic stem cell of CAA were observed by the electron miscroscope (EM).The positive exponent of the apoptosis of hematopoietic stem cell of CAA before and after the treatment with the soluble granules of Busui Shengxue were examined by the terminal deoxynucleotidyl transferasemediated dUTP nick endlabeling (TUNEL).Results:Under the EM large amount of the apoptosis of hematopoietic stem cell in the marrow of CAA were showed.The positive exponent of the apoptosis of hematopoietic stem cell of CAA before the treatment with the soluble granules of Busui Shengxue was remarkably higher than that after treatment( P 0 05).Conclusions:The effective base of the soluble granules of Busui Shengxue may be inhabit excessive apoptosis of CAA.The method of TUNEL for examining apoptosis of hematopoietic stem cell can be used to supervise the currative effects and judge the prognosis in patients with CAA.