Investigation of clindamycin-induced resistance by erythromcin in Staphylococcus by D-test

Objective:To investigate the incidence of clindamycin-induced resistance in clinical strains of Staphylococcus and help clinical physicians select appropriate drugs.Methods:To detect the erythromcin and clindamycin resistance of Staphylococcus by K-B agar diffusion method and the clindamycin-induced resistance by D-test which is recommended by CLSI/NCCLS.Results:44.78% of MRSA and 13.94% of MRCNS in 232 stains Staphylococcus are resistant to erythromcin and clindamycin.18.53% of detected Staphylococcus are positive by D-test,and 52.43% of erythromcin resistant Staphylococcus are positive.In Staphylococcus aureus which are resistant to erythromcin and sensitive to clindamycin and Staphylococcus whose coagulase is negtive,the positive rate of D-test are 65.38% and 46.42% respectively.Conclusion:The rate of clindamycin-induced resistance is high in our hospital and physicians should keep an eye on it.