Detection of inducible clindamycin resistunce in staphylococcus and analysis of their susceptibilites to clindanycin

Objective To guide clinic appropriate use of the medicine by detection of resistance of clinical dissociative staphylococcus to clindamycin.Methods To review and analyze the data of Staphylococcus separated from Jan.2007 to Jul.2008 in our hospital through Clindamycin,Erythromycin drug sensitive testing and clindamycin-induced resistance testing(D-test).Results The resistance of 229 strains of Staphylococcus aureus,136 strains of Staphylococcus epidermidin,171 strains of Staphylococcu haemolytic,25 strains of other Staphylococcus to Clindamycin are 164 strains,91 strains,113 strains,and 15 strains respectively,with the resistance rates of 71.6%,66.9%,66.1%,60.0% respectively.Among them D-test positive Staphylococcus aureus,Staphylococcus epidermidin,Staphylococcus haemolytic,and other Staphylococcus are 48,29,17,and 2 strains respectively,which occupy 67.6%,54.7%,41.5%,40.0% of their Erythromycin resistance,Clindamycin sensitive bacterium respectively,while D-test positive Methicillin resistant Staphylococcus aureus(MRSA) and Methicillin sensitive Staphylococcus aureus(MSSA) are 29 and 19 strains,which occupy 76.3% and 59.6%,Methicillin resistant Coagulase-negative staphylococcus(MRCNS) and Methicillin sensitive Coagulase-negative staphylococcus(MSCNS) are 37 and 11 stains,which aoccupy 54.4% and 35.5% respectively.Conclusion Resistance of Staphylococcus to Clindamycin is high with the D-test positive rate.Thus sensitive test and D-test of Clindamycin should be routinely performed for detection of Staphylococcus.