Detection of clindamycin-induced ressitance of erythromycin-resistant bacteria

Objective To understand the incidence of clindamycin-induced resistance in clinical strains of Staphylococcus.Methods To dermine the resistance of Staphylocococcus to erythromcin and clindamycin by K-B agar diffusion method and the clindamycin-induced resistance by D-test recommended by CLSI/NCCLS.Results There 61.53% of MRSA and 37.03% of MRCNS were resistant to erythromcin and clindamycin.There 19.16% of detected Staphylococcus were positive by D-test,and 52.87% of erythromcin- resistant Staphylococcus were positive.The positive rates of D-test of Staphylococcus aureus resistant to erythromcin and sensitive to clindamycin and and negative to coagulase were 64.28% and 47.45% respectively.Conclusion The rate of clindamycin-induced resistance is high in this hospital and reasonable and proper use of antibiotics for clinical treatment is indicated.