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STUDY ON RAT'S INSULIN RESISTANCE PREVENTED AND TREATED WITH JIAJIAN DIDANG DECOCTION

Kefu Cai

Abstract

Objective:To approach the effect and mechanism of jiajian didang decoction on insulin resistance(IR)rats.Methods:Models was made by feeding high fat and sugar diet,rats were divided into normal,model,jiajian didang decoction high,middle,low groups and positive group.FBS,FINS,ISI and blood lipid levels were determined,InRmRNA,GLUT4mRNA expression were tested by RT-PCR.Results:Jiajian didang decoction(middle and low dosage)could improved IR,up-regulate InRmRNA and GLUT4mRNA expression in rats with IR.Conclusion:Jiajian didang decoction may improve IR,up-regulating the InRmRNA and GLUT4mRNA expression maybe one of the mechanism.

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Available abstract

Key concepts: Decoction, Insulin resistance, Traditional medicine, Pharmacology, Blood sugar, Medicine, Chemistry, Insulin