Effect of Didang decoction on blood lipid, the expression of ET-1 mRNA and VCAM-1 mRNA in ovariectomized rats

Objective To observe the effect of different dose Didang decoction on blood lipid, the expression of ET-1 mRNA and VCAM-1 mRNA in ovariectomized rats. Methods 40 male rats were randomly divided into four groups, Sham group, model group, Didang decoction and Diethylstilbestrol group. Rat model with climacteric lipid abnormality were duplicated by ovariectomy. Distilled water, Dedang decoction, Diethylstilbestrol suspension were given rats in corresponding groups. After 12 weeks, TC, TG, LDL-C, HDL-C and expression of ET-1 mRNA, VCMA-1 mRNA in aorta tissue were measured. Results The contents of TC, TG and LDL-C in Didang decoction were decreased compared with those in model group (P0.05) after treatment. HDL-C was increased (P0.05). There was no significant difference between Didang decoction and Diethylstilbestrol group on the contents of TC, TG and LDL-C (P0.05). The expression of ET-1 mRNA, VCMA-1 mRNA in aorta tissue in Didang decoction were decreased compared with those in model group (P0.05) after treatment. Conclusion Didang decoction can regulate blood lipid and protect endothelial function.