2007•Zhonghua zhongyiyao xuekanRequires access

Effect of Modified Didang Decoction on GLUT4 Gene Expression in Muscle in Insulin Resistance Rats

Chai Ke-fu

Abstract

Objective:To explore the effect of modified Didang decoction on glucose transporter4(GLUT4)gene expression in muscle in insulin resistance rats.Methods:The insulin resistance rats were randomly divided into the control group,the model control group,the high,medium and low dosage of modified Didang decoction groups and Wendiya group.Reverse transcriptase polymerase chain reaction was used to observe the effect of modified Didang decoction on the GLUT4mRNA of muscle in rats.Results:The GLUT4 gene expression level was significantly higher in the high and medium dose of modified Didang decoction(P0.05 or P0.01).Conclusion:Through up-regulation on GLUT4 gene expression is possibly one of the mechanisms of modified Didang decoction in treating insulin resistance.

About this research paper

What this paper is about

Why it matters

A significance statement is not available in the OpenAlex record.

Key contribution

A contribution statement is not available in the OpenAlex record.

Method / approach

Method details are not available in the OpenAlex metadata.

Main findings

Findings are not separately available in the OpenAlex metadata.

Limitations

Limitations are not available in the OpenAlex metadata.

Applications

Application details are not available in the OpenAlex metadata.

Available abstract

Key concepts: Decoction, GLUT4, Insulin resistance, Insulin, Gene expression, Pharmacology, Gene, Medicine