Antivirus Effects of Dureping Injection on Cellular Factor of Th1/Th2 in Mice

Objective To explore the antivirus effect of Dureping Injection in mice.Methods The murine pneumonia model was establish by influenza virus strain A/FM/1/47(H1N1).The bioactivity of interleuking-4(IL-4) and interferonγ(IFN-γ) in the murine lung was detected by ELISA.The murine Death Rate was observed.Results Dureping Injection decreased the bioactivity of IL-4 and increased the bioactivity of IFN-γ.It showed 0.33 g/(kg·d) and 0.17 g/(kg·d)of Dureping Injection had significantly protective effect to death of the mouse with virus pneumonia.Conclusion Dureping Injection has an obvious effect against influenza virus FM1 strain by correcting the Th1/Th2 cell shift,regulating the bioactivities of Th1 cytokines and the bioactivies of Th2 cytokines,which reach a new balance between Th1 cell and Th2 cell.