Antiviral effect of Dureping Injection on influenza virus A

Objective To observe the antiviral effect of Dureping Injection in vitro and in vivo experiments.Methods The method of crystal violet stain was used to observe the antiviral effect in vitro of Dureping Injection(in different administrative methods) on FM1 strain of influenza virus A,time-effect relationship and the inhibitory effect on mouse viral pneumonia.Results Dureping Injection inhibited obviously the virus from adsorbing to cells and virus copy and proliferation.It also killed the virus directly at the concentration of ≥0.18 g/L.Its antiviral efficiency went to the peak on 48th hour and could be kept at the concentration of ≥0.27 g/L along with the time,and tended to decrease at a low concentration.Dureping Injection had an inhibitory effect on the pneumonia of influenza virus in mice.Conclusion Dureping Injection has a significant antiviral effect in vitro and in vivo.