Expression of VEGF and nm23 in esophageal cancer in Guangxi and the relationship between them

Objective To investigate the level of VEGF and nm23 expression in esophageal cancer and normal esophageal mucosa in Guangxi, and detect their relationships with clinical predictive indicators. Methods The levels of VEGF and nm23 expression in 80 cases of esophageal cancer and 10 cases of normal esophageal mucosa were detected by SP immunohistochemical method. Results VEGF positive expression rate in esophageal cancer was significantly higher than that of normal esophageal mucosa (P 0.05 ) . VEGF positive expression rate had no significant correlation with the patient's age, sex, and histological type(P0.05) ,but was correlation with degree of the differentiation , tumors invade depth, clinical stage, and lymph node metastasis ( P 0.05 ) . nm23 positive expression in esophageal cancer significantly lower than that of normal esophageal mucosa (P 0.05). nm23 positive expression had no significant correlation with the patient's age, sex, histological type, degree of the differentiation, and tumors invade depth (P 0.05 ) , but it was correlation with lymph node metastasis and clinical stage (P 0.05). VEGF had negative correalation with nm23 (r = 0. - 0.520, P 0.05 ). Conclusion The over-expression of VEGF and The lower-expression of nm23 were significantly correlated with the carcinogenesis of esophageal cancer in Cuangxi. And they had negative affection with each other.